One Community’s Effort to Control Genetic Disease

A new global effort to control malaria.

The time has come to resurrect a worldwide effort to control malaria, following decades of neglect during which the disease has resurged in many parts of sub-Saharan Africa and other endemic regions.

Penn Faculty Involved in International Disease Control Effort

One Health Approach to Disease Prediction and Control

Though the concept of One Health appears new for many practitioners, it extends back to ancient times. The recognition that environmental factors can impact human health can be traced as far back as to the Greek physician Hippocrates when he promoted the concept that public health dependent on a clean environment (1). In modern medicine, European physicians practicing in the 17 th and 18 th cen...

A new method for estimating the effort required to control an infectious disease.

We propose a new threshold quantity for the analysis of the epidemiology of infectious diseases. The quantity is similar in concept to the familiar basic reproduction ratio, R0, but it singles out particular host types instead of providing a criterion that is uniform for all host types. Using this methodology we are able to identify the long-term effects of disease-control strategies for partic...

Histocompatibility-linked Genetic Control of Disease Susceptibility

Acute necrotizing inflammatory disease after intracerebral injection of LCM virus is largely dependent on the host immune response to the virus and is controlled, in part, by a dominant gene which is closely linked to the H-2 locus. The F(1) hybrid (H-2(q/k)) from mating a susceptible SWR/J mouse (H-2(q/q)) to a resistant C3H/HeJ mouse (H-2(k/k)) is susceptible to LCM virus disease. When such h...